T Follicular Helper Cell Biology: A Decade of Discovery and Diseases
T**辅助细胞生物学：发现和疾病的十年
摘要：
Helping B cells and antibody responses is a major function of CD4^+ T cells.It has been 10 years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular helper (Tfh) differentiation and the requirement of Tfh cells as the specialized subset of CD4^+ T cells needed for germinal centers (the microanatomical sites of B cell mutation and antibody affinity maturation) and related B cell responses.A great deal has been learned about Tfh cells in the past 10 years, particularly regarding their roles in a surprising range of diseases.Advances in the understanding of Tfh cell differentiation and function are discussed, as are the understanding of Tfh cells in infectious diseases, vaccines, autoimmune diseases, allergies, atherosclerosis, organ transplants, and cancer.This includes discussion of Tfh cells in the human immune system.Based on the discoveries to date, the next decade of Tfh research surely holds many more surprises.
帮助B细胞和抗体反应是CD4^ + T细胞的主要功能。自Bcl6作为T滤泡辅助（Tfh）分化的谱系定义转录因子以及Tfh细胞作为生发中心所需的CD4 ^ + T细胞的特定子集（微观解剖学位点）的需要已经过去10年了。 B细胞突变和抗体亲和力成熟）和相关的B细胞反应。在过去10年中，人们已经了解了很多关于Tfh细胞的知识，特别是关于它们在一系列令人惊讶的疾病中的作用。讨论了对Tfh细胞分化和功能的理解的进展，以及对传染病，疫苗，自身免疫疾病，过敏，动脉粥样硬化，器官移植和癌症中Tfh细胞的理解。这包括讨论人体免疫系统中的Tfh细胞。根据迄今为止的发现，Tfh研究的下一个十年肯定会有更多的惊喜。
T**辅助细胞生物学：发现和疾病的十年
摘要：
Helping B cells and antibody responses is a major function of CD4^+ T cells.It has been 10 years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular helper (Tfh) differentiation and the requirement of Tfh cells as the specialized subset of CD4^+ T cells needed for germinal centers (the microanatomical sites of B cell mutation and antibody affinity maturation) and related B cell responses.A great deal has been learned about Tfh cells in the past 10 years, particularly regarding their roles in a surprising range of diseases.Advances in the understanding of Tfh cell differentiation and function are discussed, as are the understanding of Tfh cells in infectious diseases, vaccines, autoimmune diseases, allergies, atherosclerosis, organ transplants, and cancer.This includes discussion of Tfh cells in the human immune system.Based on the discoveries to date, the next decade of Tfh research surely holds many more surprises.
帮助B细胞和抗体反应是CD4^ + T细胞的主要功能。自Bcl6作为T滤泡辅助（Tfh）分化的谱系定义转录因子以及Tfh细胞作为生发中心所需的CD4 ^ + T细胞的特定子集（微观解剖学位点）的需要已经过去10年了。 B细胞突变和抗体亲和力成熟）和相关的B细胞反应。在过去10年中，人们已经了解了很多关于Tfh细胞的知识，特别是关于它们在一系列令人惊讶的疾病中的作用。讨论了对Tfh细胞分化和功能的理解的进展，以及对传染病，疫苗，自身免疫疾病，过敏，动脉粥样硬化，器官移植和癌症中Tfh细胞的理解。这包括讨论人体免疫系统中的Tfh细胞。根据迄今为止的发现，Tfh研究的下一个十年肯定会有更多的惊喜。
